The humans and animals believe a werewolf is on the loose, and former hunter Shaw uses the opportunity to re-open the season. Boog, Elliot, and Mr. Weenie have to face their fears and find the werewolf to get the season closed permanently.
Growing up can be a bumpy road, and it\'s no exception for Riley, who is uprooted from her Midwest life when her father starts a new job in San Francisco. Like all of us, Riley is guided by her emotions - Joy, Fear, Anger, Disgust and Sadness. The emotions live in Headquarters, the control center inside Riley\'s mind, where they help advise her through everyday life. As Riley and her emotions struggle to adjust to a new life in San Francisco, turmoil ensues in Headquarters. Although Joy, Riley\'s main and most important emotion, tries to keep things positive, the emotions conflict on how best to navigate a new city, house and school.
When Earth is taken over by the overly-confident Boov, an alien race in search of a new place to call home, all humans are promptly relocated, while all Boov get busy reorganizing the planet. But when one resourceful girl, Tip, manages to avoid capture, she finds herself the accidental accomplice of a banished Boov named Oh. The two fugitives realize there’s a lot more at stake than intergalactic relations as they embark on the road trip of a lifetime.